Antonym for Nourish

Consider drain [MWD]

to exhaust physically or emotionally: feeling drained at the end of a long workday

You could say

Working all day in the hot sun had quickly drained her.

The word famish when used transitively would seem to me an exact antonym of nourish.

There is nothing in the OED which suggests it is archaic - and it would seem appropriate to use in a sentence such as -

Assad's forces had famished the region of Aleppo into near-starvation

sense 1.

1. trans. To reduce to the extremities of famine and hunger; to starve. Also, †to famish away.

Most recent example:

a1822 Shelley Prince Athanase in Posthumous Poems (1824) 106 Those false opinions which the harsh rich use To blind the world they famish for their pride. OED.

There is, of course an intransitive form, which is in everyday used as famished - meaning, extremely hungry.

Well, malnourished is a word which is the antonym of nourished. To malnourish is not in the dictionary, but I bet you could get by with it in casual conversation.

You could use depleted, or in a more casual context you could also use deflated.

The original question stated that "starve" doesn't suit the criteria because it implies death or suffering from malnourishment, but this is not necessarily the case as pointed out in @JEL's comment.

Starve can also mean "to deprive of nourishment". For reference, see point 5 in wiktionary definition:

https://en.wiktionary.org/wiki/starve